{"id":10701,"date":"2019-05-02T16:27:41","date_gmt":"2019-05-02T15:27:41","guid":{"rendered":"https:\/\/sclerodermie.ca\/?p=10701"},"modified":"2024-03-14T10:31:51","modified_gmt":"2024-03-14T14:31:51","slug":"precision-medicine-in-cellular-epigenomics","status":"publish","type":"post","link":"https:\/\/sclerodermie.ca\/en\/precision-medicine-in-cellular-epigenomics\/","title":{"rendered":"Precision Medicine in Cellular Epigenomics"},"content":{"rendered":"<div>\n<div class=\"field field--name-field-project-status field--type-list-text field--label-inline clearfix\">\n<p class=\"field__label\"><span style=\"font-size: 10pt;\">Status: Active<br \/>\n<\/span><span style=\"font-size: 10pt;\">Competition: 2017 Bioinformatics and Computational Biology Competition<br \/>\n<\/span><span style=\"font-size: 10pt;\">Sector: Health<br \/>\n<\/span><span style=\"font-size: 10pt;\">Genome Centre(s): G\u00e9nome Qu\u00e9bec<br \/>\n<\/span><span style=\"font-size: 10pt;\">Project Leader(s):\u00a0Celia Greenwood (Lady Davis Institute for Medical Research), Karim Oualkacha (Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al)<\/span><\/p>\n<p><strong style=\"color: #000000; font-size: 10pt;\">Project Description:\u00a0<\/strong><\/p>\n<\/div>\n<\/div>\n<div class=\"field__items\">\n<div class=\"field__item even\">\n<p class=\"xdefault\" style=\"text-align: justify;\"><span lang=\"EN-US\" style=\"font-size: 10pt;\">DNA methylation refers to the attachment of a methyl molecule to our DNA. This chemical binding makes the DNA inaccessible, and provides a mechanism to influence which parts of the DNA are active or inactive. Since DNA methylation can vary across cell types, with disease, with exposures to contaminants, and with other factors such as genetic factors and age, many clinicians and researchers are excited to identify which parts of the genome are associated with certain diseases or exposures. This could be used to understand mechanisms of disease and to provide potential targets\u00a0of intervention. for these reasons, there is increasing interest to study DNA methylation in scleroderma.<\/span><\/p>\n<p class=\"xdefault\" style=\"text-align: justify;\"><span lang=\"EN-US\" style=\"font-size: 10pt;\">It has recently become technically and financially feasible to perform single nucleotide-resolution measurement of DNA methylation on a large scale across the genome, using a method called bisulfite sequencing. However, the data are noisy and many measures can be missing. Appropriate methods of analysis for this voluminous and highly correlated data are currently unsatisfactory.<\/span><\/p>\n<p class=\"xdefault\" style=\"text-align: justify;\"><span lang=\"EN-US\" style=\"font-size: 10pt;\">We have assembled a team of experts including leading methodological statisticians, scientific researchers in several domains such as scleroderma, as well as\u00a0asthma and behavioural development, and experienced bioinformaticians. Together we will develop an algorithm and software package to analyze large scale, high dimensional DNA methylation data so that we can profit from the potential hidden in the messy data. We have already a prototype method in place that shows excellent performance.<\/span><\/p>\n<p class=\"xmsonormal\" style=\"text-align: justify;\"><span lang=\"EN-US\"><span style=\"font-size: 10pt;\">Strong support for the ideas in our study have been obtained from patient-led associations including Scleroderma Quebec, and also from two Montreal companies, one that develops machine learning methods and the other that provides a high-performance computational platform. Leading epigenetic researchers and consortia have also expressed their interest in our research. Understanding of epigenetic contributions to disease will be revolutionized through this project.<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Status: Active Competition: 2017 Bioinformatics and Computational Biology Competition Sector: Health Genome Centre(s): G\u00e9nome Qu\u00e9bec Project Leader(s):\u00a0Celia Greenwood (Lady Davis Institute for Medical Research), Karim Oualkacha (Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al) Project Description:\u00a0 DNA methylation refers to the attachment of a methyl molecule to our DNA. This chemical binding makes the DNA inaccessible, and provides [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[71],"tags":[],"class_list":["post-10701","post","type-post","status-publish","format-standard","hentry","category-current-research-project-summaries-canadian-scleroderma-research-group"],"acf":[],"_links":{"self":[{"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/posts\/10701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/comments?post=10701"}],"version-history":[{"count":1,"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/posts\/10701\/revisions"}],"predecessor-version":[{"id":10702,"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/posts\/10701\/revisions\/10702"}],"wp:attachment":[{"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/media?parent=10701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/categories?post=10701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sclerodermie.ca\/en\/wp-json\/wp\/v2\/tags?post=10701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}